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to recover completely. In premarketing clinical trials, 2 patients are known tohave developed a serious cutaneous systemic illness. In neither patient wasthere an unequivocal diagnosis, but 1 was considered to have a leukocytoclasticvasculitis, and the other, a severe desquamating syndrome that was consideredvariously to be a vasculitis or erythema multiforme. Other patients have hadsystemic
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